Trypanothione
WebThe lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain inhibitory compound found using bioinformatics tools. The half … In enzymology, a trypanothione synthase (EC 6.3.1.9) is an enzyme that catalyzes the chemical reaction glutathione + glutathionylspermidine + ATP N1,N8-bis(glutathionyl)spermidine + ADP + phosphate The 3 substrates of this enzyme are glutathione, glutathionylspermidine, and ATP, whereas its 3 products are N1,N8-bis(glutathionyl)spermidine, ADP, and phosphate.
Trypanothione
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WebThe antiparasitic mechanisms of these molecules remain partially understood. However, a few studies have proposed the trypanothione redox system as a target, in resemblance to the mammalian thioredoxin system, pointed as the main target for several gold compounds with significant antitumor activity. WebJun 23, 2016 · Trypanosomatids are protozoan parasites with a unique trypanothionebased thiol redox metabolism. Mediated by the small oxidoreductase tryparedoxin, …
WebMar 3, 2008 · The bifunctional trypanothione synthetase-amidase catalyzes biosynthesis and hydrolysis of the glutathione-spermidine adduct trypanothione, the principal … WebTrypanothione in the depressed state is essential for parasite life; it prevents the production of oxidative stress in the parasite. A mutation in the gene structure of this enzyme is likely to play an important role in the development of drug resistance ( 8 , 13 – 17 ).
WebDec 14, 2024 · - Predicted the structure of the enzyme Trypanothione Reductase in Leishmania Donovani using BLAST, Chimera, and Modeller. - Determined various … WebApr 1, 2013 · Trypanothione reductase (TryR) is a validated drug target against Leishmaniasis. Using integrated computational and experimental approaches, the authors report doxorubicin and mitomycin C, ...
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WebNADPH binding to trypanothione reductase precedes compound 3f/enzyme association. Compound 3f behaves as a subversive substrate of trypanothione reductase. Ver publicación. Tripeptides as Integrin-Linked Kinase Modulating Agents Based on a Protein–Protein Interaction with α-Parvin pool tankless water heater partsWebAttempted the ligase-independent cloning of the trypanothione reductase gene from the procyclic form of sp. Trypanosoma brucei. This debilitating blood parasite is a major … shared ownership welwyn garden cityWebMar 21, 2024 · Abstract. Trypanothione synthetase (TryS) catalyses the synthesis of N 1,N 8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol … pool tanning ledge depthWebAug 11, 2011 · Auranofin is a gold(I)-containing drug in clinical use as an antiarthritic agent. Recent studies showed that auranofin manifests interesting antiparasitic actions very likely arising from inhibition of parasitic enzymes involved in the control of the redox metabolism. Trypanothione reductase is a key enzyme of Leishmania infantum polyamine-dependent … shared ownership wellington somersetWebJun 13, 2005 · Trypanothione-disulfide reductase activity Specific Function Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione … shared ownership walsallWebLeishmania spp. are responsible for up to 1 million new cases each year. The current therapeutic arsenal against Leishmania is largely inadequate, and there is an urgent need … pool tanning ledge chaise loungersWebDec 18, 2024 · Trypanothione reductase (TR), a flavoprotein oxidoreductase is an important therapeutic target for leishmaniasis. Ligand-based pharmacophore modelling and molecular docking were used to predict selective inhibitors against TR. Homology modelling was employed to generate a three-dimensional structure of Leishmania major trypanothione … shared ownership wallington surrey