WebJun 23, 2015 · Randomized, Double-Blind, Phase III Trial of Olaparib vs. Placebo in Patients with Advanced FIGO Stage IIIB - IV High Grade Serous or Endometrioid Ovarian, Fallopian Tube, or Peritoneal Cancer treated with standard First-Line Treatment, Combining … Web2 days ago · A lawyer for a columnist who says former President Donald Trump raped her over 25 years ago in a Manhattan department store is urging a judge to reject his request to delay this month’s civil ...
SOLO-1 Phase III trial demonstrates Lynparza maintenance ... - AstraZeneca
WebJan 28, 2024 · Case 1: Key Clinical Trials for PARP Inhibitors in Advanced Ovarian Cancer Jan 28, 2024 Experts in gynecologic oncology review data and clinical implications for the use of PARP inhibitors from the GOG-0218, SOLO-1, PRIMA, and PAOLA-1 trials in advanced ovarian cancer. EP: 1. EP: 2. EP: 3. EP: 4. Now Viewing EP: 5. EP: 6. EP: 7. … WebSep 28, 2024 · PAOLA-1 is a double-blind Phase 3 trial evaluating the efficacy and safety of LYNPARZA added to SoC bevacizumab vs. bevacizumab alone, as a first-line maintenance treatment for newly-diagnosed advanced FIGO Stage III-IV high grade serous or … bitslice computer
Homologous Recombination Repair Gene Mutations to Predict …
WebJan 30, 2024 · The phase III randomized PAOLA-1 trial established maintenance olaparib plus bevacizumab as a standard of care for newly diagnosed advanced ovarian cancer (OC), particularly in patients with homologous recombination deficiency (HRD)–positive tumors. WebPAOLA-1/ENGOT-ov25 (NCT02477644) is the first phase III trial to evaluate the efficacy and safety of a PARP inhibitor with bev as first-line (1L) maintenance therapy for advanced OC, regardless of BRCA1/2 mutation (BRCAm) status. Methods. PAOLA-1 is a randomized, double-blind, international phase III trial. WebThe trial was designed to detect a treatment effect (hazard ratio for disease progression or death) of 0.75, translating to an improvement in median progression-free survival from 15.8 months in... bitslicer windows10 download