Ototoxicity from cisplatin

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August undefined, 2024

WebFeb 1, 1991 · The main known side effects of cisplatin are a high emetogenic potential and various organotoxic effects. Cisplatin can be nephrotoxic (8), ototoxic (9) and neurotoxic … WebCisplatin-induced hearing loss (CIHL), which is permanent and mostly bilateral, can negatively affect academic development and social integration, especially in children. 1 To the best of our knowledge, cisplatin ototoxicity has not been studied in detail, and the mechanisms responsible for the degeneration of cochlear structures are not completely …

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to

WebSep 2, 2024 · Ototoxicity From Cisplatin: Who Is at Risk and Who May Benefit From Treatment? The highest buildup of cisplatin was in the stria vascularis, which helps … WebApr 3, 2024 · Cisplatin is a chemotherapeutic agent commonly used to treat a variety of cancer types, but its use comes with a risk of hearing impairment or ototoxicity. tracy industries

(PDF) Ototoxicity of cisplatin - ResearchGate

http://mdedge.ma1.medscape.com/fedprac/article/227870/oncology/improving-ototoxicity-monitoring-cisplatin-therapy-va-northeast-ohio WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This hearing … WebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative risk … tracy indian store

Mechanisms of Cisplatin-Induced Ototoxicity and …

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WebMar 6, 2024 · With 74% of testicular cancer survivors reporting hearing loss in a recent study, one expert advised patients to advocate for themselves and their hearing before, during and after cancer treatment with cisplatin-based chemotherapy. Three out of four testicular cancer survivors reported experiencing ototoxicity — damage to the inner ear caused ... WebCisplatin is a highly effective antitumor drug generally used in the treatment of solid malignant tumors. However, cisplatin causes severe side effects such as bone marrow … tracy industries moparWebApr 7, 2024 · Determining the mechanism behind this adverse effect could possibly aid in developing strategies to mitigate it. Potential mechanisms for cisplatin-induced ototoxicity include direct cytotoxicity from the platinum-containing agent, direct damage to DNA, or induction of apoptosis through mechanisms involving cell cycle arrest and/or generation … the royal pacific hotel and towers hong kong

"WebJun 10, 2010 · Objective . Combined cisplatin (CDDP) and radiotherapy is increasingly being used to treat advanced head and neck cancers. As both CDDP and radiation can cause hearing loss, it is important to have a better understanding of the cellular and molecular ototoxic mechanisms involved in combined therapy. Procedure . The effects of CDDP, … " - Ototoxicity from cisplatin

Ototoxicity from cisplatin

Uncovering Clues That Explain the Ototoxicity of Cisplatin

WebOf these reactions, cisplatin-induced nephrotoxicity (CIN), cisplatin-induced peripheral neuropathy (CIPN), and cisplatin-induced ototoxicity (CIO) are the three most common of several CITs recognised thus far. While the anti-cancer activity of cisplatin is well understood, the mechanisms driving its toxicities have only begun to be defined. WebApr 5, 2024 · Ototoxicity is defined as damage to structures and function of the auditory-vestibular system caused by exogenous agents, such as chemotherapy. 1 Cisplatin is a …

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Webpermanent. Symptoms of ototoxicity include tinnitus, dizziness, and difficulty understanding speech in noise. Approximately 4 million patients annually in the United States are at risk for hearing loss from aminoglycoside antibiotics (e.g. gentamicin) and plati-num-based chemotherapy agents (e.g., cisplatin). Loop WebApr 9, 2024 · EU's CHMP Recommends Injection Against Pediatric Chemo-Induced Ototoxicity. Apr 9, 2024. Russ Conroy. Findings from 2 phase 3 trials support the recommendation to approve sodium thiosulfate to reduce the risk of cisplatin-related hearing loss in pediatric patients with solid tumors in Europe. The European Medicine …

WebJun 21, 2024 · The relative risk of any hearing loss with cisplatin–sodium thiosulfate treatment was 0.52 (95% CI, 0.33 to 0.81), which translates to a 48% lower risk with … WebJan 26, 2024 · Cisplatin, a platinum-based chemotherapy drug, is commonly used for the treatment of many cancers, including bladder, ovarian, and testicular cancers. But …

WebNov 29, 2024 · STAT1 and STAT3 have opposing effects in the cochlea. STAT1 is pro-inflammatory and appears to mediate apoptosis in the cochlea resulting from cisplatin … WebAug 6, 2015 · The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by conducting different omics data analyses, we demonstrated that cisplatin …

WebJun 18, 2024 · Ototoxicity monitoring is uncommon in South Africa, despite the increased use of ototoxic medication to manage the burden of disease in the country. The …

WebObjectives: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined. Materials and methods: In this prospective, observational cohort study, 206 adult HNSCC patients underwent … tracy industries ontario caWebSep 24, 2024 · The effects of cisplatin ototoxicity are irreversible and permanent; certain is the fact that it will decrease in the quality of life of a cancer survivor. Varying degrees of damage have been reported: some patients experience persistent ringing in the ear or dizziness, while others found it difficult to communicate because they cannot hear properly. the royal pacificWebIn cisplatin-treated guinea pigs, pretreatment with A666-DEX-NP effectively preserved OHCs and showed significant hearing protection at 4, 8, and 16 kHz as compared to … the royal pacific hotel kowloonWebApr 9, 2024 · The European Commission will review the CHMP’s recommendation and issue a decision on the injection’s approval by early June 2024. The CHMP based its … tracy indoor shooting rangeWebJun 3, 2024 · Cisplatin is a chemotherapeutic used in cancer patients to treat solid tumors. It contributes to the approximately 80% five-year survival rate for childhood cancer … tracy infant center cerritosWebApr 4, 2024 · Background Concurrent chemoradiotherapy using weekly cisplatin remains standard of care for locally advanced cervical cancer in Sub-Saharan Africa. While … tracy in eastendersWebJul 24, 2024 · Mechanisms of platinum ototoxicity. The hearing loss caused by cisplatin and carboplatin is due to degeneration of the cochlear hair cells and supporting cells (Rybak et al, Citation 2007; Brock et al, Citation 2012).The outer hair cells are damaged before the inner hair cells, and platinum initially affects hair cells at the base of the cochlea, where … tracy infant center