WebAug 2, 2024 · We examined Casz1-cKO rods from the peripheral retinas of Casz1 Flox/Flox; α-Pax6::Cre-cKO animals, where Cre is expressed , and compared these with rods from … WebApr 27, 2001 · Function. Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal ...
Upregulation of Myt1 Promotes Acquired Resistance of Cancer …
WebJan 2, 2012 · We also found that the NB tumor suppressor genes CASZ1, CLU, NGFR, and RUNX3 are direct targets of H3K27me3-mediated gene silencing by EZH2. HDAC inhibition increased CASZ1 expression and decreased binding of PRC2 and the H3K27me3 enrichment on the CASZ1 promoter. Our findings suggest EZH2-mediated H3K27me3 is an important … WebActs as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however ... folded notch antenna
Single-cell transcriptomic landscapes of the otic neuronal …
WebThe myelin transcription factor 1 (Myt1) gene family is com-prised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To under-stand the mechanism by which this family regulates neural differentiation, we searched for interaction partners ... WebSep 3, 2024 · Candidate genes located within the two loci, CASZ1 and RXFP2, are expressed in human and mouse adrenals in different cell clusters. Their overexpression in adrenocortical cells suppresses mineralocorticoid output under basal and stimulated conditions, without affecting cortisol biosynthesis. Our study identifies the first risk loci … WebJun 1, 2015 · CASZ1 is a para-zinc-finger transcription factor that has been shown to be expressed during and required for vertebrate heart development, with depletion of Casz1 … folded note card template