Web12 aug. 2014 · Mechanistically, higher sialic acid levels in LDL might block the interaction of the particle with arterial wall proteoglycans, linking LDL hypo-glycosylation with atherogenesis , . Two strengths of the study were the careful selection of both the (optimally) healthy controls and the MetSyn subjects [64] , [65] and the use of an inexpensive (but … Web14 apr. 2024 · SCARF 2 was initially identified in a human endothelial cell line and classified as a member of the scavenger receptor family [].The scavenger receptor family includes a group of functionally defined membrane receptors that share a common ability to bind and internalize modified forms of low-density lipoproteins (LDL) such as acetylated LDL …
Protein N-Glycosylation in Cardiovascular Diseases and Related …
Web11 apr. 2024 · LDL (-) is a minor form of LDL present in blood that is present in increased amounts in pathologies with increased cardiovascular risk. The enzymes involved are platelet activating factor acetylhydrolase (PAF-AH) which degrades oxidized phospholipids, type C phospholipase-like (lysoPLC) activity that acts on lysophospholipids, … Web1 aug. 2024 · Our findings establish B4GALT1 as a novel gene associated with lower LDL-C and fibrinogen and suggest that targeted modulation of protein glycosylation may represent a therapeutic approach to... chikmagalur to bangalore airport
RCSB PDB - 1N7D: Extracellular domain of the LDL receptor
Web17 nov. 2015 · As an independent means to modify protein glycosylation, we used Chinese hamster ovary ldl-D cells defective in UDP-Gal/UDP-GalNAc 4-epimerase in which N- … Web1 aug. 1993 · LDL glycosylation of 2.20% t 0.11% and 2.89% t 0.46o for normocholesterolaemic and hypercholesterolaemic diabetic LDL was significantly higher than that for the non-diabetic control subjects of 1.60I t 0.12I (P < 0.02). There was a significant positive correlation (P < 0.005) between LDL glycosylation and LDL oxidation. Web11 apr. 2024 · Electronegative LDL (LDL(−)) is a minor form of LDL present in blood for which proportions are increased in pathologies with increased cardiovascular risk. In vitro studies have shown that LDL(−) presents pro-atherogenic properties, including a high susceptibility to aggregation, the ability to induce inflammation and apoptosis, and … chikmagalur to jog falls