Ilir autophagy database warwick.ac.uk
WebNational Center for Biotechnology Information Webcontact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 01. Dec. 2024 [Cell Cycle 8:14, 2260-2265; 15 July 2009]; ©2009 Landes Bioscience 2260 Cell Cycle 2009; Vol. 8 Issue 14 Autophagy is a membrane-trafficking process that serves to deliver cytoplasmic ...
Ilir autophagy database warwick.ac.uk
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WebAlong these lines, we developed iLIR, a freely available web resource, which provides in silico tools for assisting the identification of novel LIRCPs. Given an amino acid … WebSARs act by recognizing and sorting diverse cargo substrates (e.g., proteins, organelles, pathogens) to the autophagic machinery. Known SARs are characterized by a short …
WebAutophagy is a process of self-digestion that occurs in eukaryotic cells. Autophagy involves the formation of a membrane around a region of the cytoplasm, sequestering macromolecules like proteins and organelles, and the fusion of the resultant vesicle with a lysosome in which the contents are degraded. Web2 aug. 2016 · The iLIR database is developed, listing all the putative canonical LIRCPs identified in silico in the proteomes of 8 model organisms using the iL IR server, and a …
Web1 jan. 2024 · Autophagy is a highly conserved, multistep degradative process dedicated to maintaining cellular homeostasis [ 1, 2 ]. In healthy cells, autophagy is constitutively involved in organelle and protein quality control by eliminating dysfunctional organelles and aggregated/misfolded proteins, respectively [ 2, 3, 4 ]. WebHAMdb: a database of human autophagy modulators with specific pathway and disease information [1] 研究背景 研究自噬的意义： 自噬在细胞生物学中的重要作用及其巨大的治疗潜力，寻找自噬的调节因子可能成为临床治疗的新策略。 近年来大量实验表明，抑制自噬可以提高肿瘤细胞对放疗、化疗和分子靶向药物的敏感性，增加细胞死亡，从而提高治疗 …
WebMacroautophagy (hereafter autophagy) is an intracellular degradation pathway found in most eukaryotes in which different cellular components are sequestered within double-membrane vesicles called autophagosomes and transported to lytic compartments (lysosomes or vacuoles; Yang and Klionsky, 2010; Ohsumi, 2014 ).
WebAutophagy UK Network Meeting 2024 at University of Birmingham Our 8th annual national meeting for researchers in the field of autophagy will be held on 19-20 June 2024 at Edgbaston Park Hotel and Conference Centre in University of Birmingham. Organizers: Sovan Sarkar (University of Birmingham, UK), Viktor Korolchuk (Newcastle University, UK). formerly castlight accountWeb17 nov. 2024 · The process of autophagy is completed in five steps: initiation, elongation, autophagosome formation, fusion and degradation. Each step is monitored and modulated by a group of genes called ATG. Autophagy-related diseases can be categorized into two parts: organ-specific (shown in the inner circle) and multisystemic (shown in the outer … formerly called edoWeb(2014) Kalvari et al. Autophagy. ... Article OPEN ACCESS. iLIR: A web resource for prediction of Atg8-family interacting proteins. Kalvari I; Tsompanis S; Mulakkal N; et al. See more; Autophagy. DOI: 10.4161/auto.28260. 126 Citations. Citations of this article. 151 Readers. Mendeley users who have this article in their library. formerly cantles mammasWeb26 feb. 2014 · Thus, autophagy plays an important role in the cellular mechanisms for quality control of proteins and organelles. 3 Importantly, there is growing evidence that autophagy plays central roles in key processes, including differentiation (e.g., cell remodeling), 4 development (e.g., embryogenesis), 4-6 miRNA regulation, 7 innate and … formerly certifyWeb12 apr. 2024 · To predict LC3-interacting region (LIR) motif among these DEGs, the iLIR database was selected to assess specific short linear sequences. To obtain potential upstream miRNA targets of these DEGs, the mRNA-miRNA interaction networks were predicted by miRWalk database. formerly captureWebIf you use iLIR please cite: Kalvari I, Tsompanis S, Mulakkal NC, Osgood R, Johansen T, Nezis IP, Promponas VJ. iLIR: A web resource for prediction of Atg8-family interacting proteins. Autophagy 2014; 10:166 - 178; PMID: 24589857 ; [ Open access full text ] formerly castlight credit searchWeb25 jun. 2024 · AIM/LIR-motifs have been extensively studied during the last fifteen years, since they can uncover the underlying biological mechanisms and possible substrates for this key catabolic process of eukaryotic cells. formerly caterpillar university