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Ggt1-cre

WebGgt1-Cre mice were crossed with FAN1 loxP/loxP mice to inactivate FAN1 expression in kidney proximal tubules. Kidney injury was induced by cisplatin administration (5 weekly injections of 2 mg/kg) or unilateral ureteral obstruction (UUO). Histological analysis was performed using hematoxylin and eosin, periodic acid–Schiff, or Masson’s ... http://www.informatics.jax.org/recombinase/specificity?id=MGI:3811269&system=renal+%26+urinary+system

Kidney Week - Abstract Details (2024) - American Society of …

WebJul 5, 2024 · In Vgat-Cre neg lamina II neurons, CNO produced facilitation of A fibre-mediated polysynaptic excitatory responses, an effect that required N-methyl-D-aspartate (NMDA) receptor activation. The CNO-induced nocifensive behaviours were also reduced by NMDA receptor antagonism. Moreover, these nocifensive behaviours were suppressed … WebTg (Ggt1-cre/ERT2)1Pepe. Mutation details : 411 bp of the mouse Ggt1 promoter was used to drive expression of an inducible cre/ERT2fusion in the proximal tubule of the kidney. One founder was created with 50 to 70 copies of the transgene integrated into the X chromosome. ( J:137094 ) snagit unable to output screen capture https://mission-complete.org

All Phenotypes Tg(Ggt1-cre)M3Egn MGI Mouse - Mouse …

WebNov 22, 2024 · We used an initial pair of GGT1-Cre primers shown in Figure 1B, which were 400 bp in size. PCR primer sequences are listed in Table 1. Murine model of cisplatin-induced nephrotoxic AKI. Cisplatin nephrotoxic AKI was induced in randomly distributed male and female Trip13 Stop/Stop and GGT1-Cre +/– Trip13 Stop/Stop mice (aged 8–12 … WebNov 16, 2024 · Transgenic B6.Cg-Tg(Ggt1-cre)M3Egn/J mice that expressed Cre recombinase under the control of gamma-glutamyltransferase 1 (Ggt1) promoter … WebSep 4, 2024 · In Ggt1-Cre mice, Cre recombinase is expressed in RTECs 7–10 days after birth, and as a result Cre-mediated gene ablation is unlikely to influence normal renal development . Vgf PT−/− mice were indistinguishable from WT littermates and normal renal function was not evidently influenced by Vgf deficiency in RTECs ( Fig. S3 ). rmwbh frisco

All Phenotypes Tg(Ggt1-cre)M3Egn MGI Mouse - Mouse …

Category:021504 - Vil-Cre 1000 Strain Details - The Jackson Laboratory

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Ggt1-cre

PTEN alleviates maladaptive repair of renal tubular …

WebNov 27, 2024 · In Ggt1-Cre mice, Cre recombinase is expressed in RTECs 7–10 days after birth, and as a result Cre-mediated gene ablation is unlikely to influence normal renal development (32). Vgf PT−/− mice were indistinguishable from WT littermates and normal renal function was not evidently influenced by Vgf deficiency in RTECs ( Fig. S3 ). WebFeb 1, 2024 · Additionally, quantitative proteomics and validated studies showed HMGCS2, a key enzyme for ketone synthesis, was increased in GGT1-cre DcR2 f/f mice compared with WT. And the levels of urinary and serum β-hydroxybutyrate were higher in GGT1-cre DcR2 f/f mice, suggesting DcR2 affects the synthesis of β-hydroxybutyrate through …

Ggt1-cre

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WebApr 5, 2014 · 目前已有的PEPCK-cre工具鼠仅有Hprttm1(Pck1-cre)Vhh变型启动子使肝中cre表达降低60%，而肝中cre表达提高10倍。 同时需注意此工具鼠中同时敲除了Hprt基 … WebAir Intake Screen - Big Rig World carries Genuine OEM and Aftermarket parts to repair your vehicle at the lowest prices. Brand: TRP TRPPC Unit of Measure: Each VMRS Code: …

WebMar 13, 2024 · The Ggt1-Cre mice have a mix of BALB/cJ and C57BL/6 background. Animal models of acute kidney injury Given that AKI is associated with distinct disease conditions, multiple mouse models have been developed. 20 Ischemia, cisplatin, and rhabdomyolysis-associated AKI was triggered in male mice aged 8–12 weeks using …

WebIn this study, we crossed Trp53 and Pten conditional knockout mice with Ggt1-Cre mice to generate a Ggt1-Cre; Trp53 LoxP/LoxP; Pten LoxP/LoxP; YFP LoxP/LoxP (GPPY) … WebSep 17, 2024 · Selective deletion of Arg2 in endothelial cells (Tie2 Cre /Arg2 fl/fl) reduced the level of fibrosis after UUO. In contrast, selective deletion of Arg2 specifically in …

WebMay 18, 2015 · Inbred male DBA/2 mice were from Taconic. We have previously described the generation of the Ggt1-Cre transgenic mouse line ; this Ggt1-Cre mouse line was …

Web012841 STOCK Tg(Ggt1-cre)M3Egn/J These GT.cre transgenic mice express Cre recombinase in cortical tubular epithelium of the kidney and may be useful for generating … rmwb hrWebrenal/urinary system. increased kidney weight ( J:175630 ) • at 20 months of age. albuminuria ( J:175630 ) • in angiotensin II-treated mice. abnormal kidney physiology ( J:175630 ) • at 20 months of age, mice exhibit increased renal injury index with increased macrophage, neutrophil, and lymphocyte infiltration compared with wild-type mice. rmwb housingWebTo breed corin kcKO mice, Cor flox mice were bred with Ggt1-Cre mice (Tg(Ggt1-cre)M3Egn/J, Jackson Laboratory, Bar Harbor, ME, USA), expressing renal Cre under the Ggt1 promoter [84,85] . The mice were crossed (>10 generations) into the C57BL/6J background. WT C57BL/6J mice were used as controls. rmwb ice roadWebApr 27, 2024 · Renal fibrosis in wild type and PT-Sirt6KO (Sirt6 flox/flox; Ggt1-Cre +) mice was induced by UUO surgery. After seven days, histologic examination and Western blot analysis were performed to examine extracellular matrix (ECM) protein expression. We evaluated inflammatory cytokine and cell adhesion molecule expression after ureteral … snagit version 9 downloadWebApr 21, 2024 · l Ggt1-Cre mice were crossed with ROSA mT/mG mice to generate transgenic mice that express membrane-localized EGFP in renal tubular epithelial cells. … rmwbh pc houston txWebMar 1, 2024 · wcn23-0488 decoy receptor 2 mediates tubular maladaptive repair by regulating ketogenesis after acute kidney injury rmwb incentivesWebThe genotyping protocol (s) presented here have been optimized for reagents and conditions used by The Jackson Laboratory (JAX). To genotype animals, JAX recommends researchers validate the assay independently upon receipt of animals into their facility. Reaction cycling temperature and times may require additional optimization based on the ... rmwb inclusion