Web5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic … WebApr 1, 2024 · CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF. ... (CST), a gene essential for spermatogenesis, is regulated by the CTCF ...
National Center for Biotechnology Information
WebCTCF mutations or deletions have been found in many breast, prostate, and Wilms tumors (10,11). Expression of BORIS is restricted to spermatocytes and is mutually exclusive of CTCF (3). In cells expressing BORIS, promoters of … WebJan 14, 2024 · The 3D structures of chromosomes in vertebrate cells play a critical role in nearly all nuclear processes, including transcriptional control of gene expression, replication of DNA, repair of DNA damage, and splicing of messenger RNA (1–4).A key player in chromatin organization is the CCCTC-binding factor (CTCF), an 11-zinc finger (11ZF) … sialkot manufacturing exports
Canonical WNT signaling-dependent gating of MYC requires a
WebPreviously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined. ... By gene expression profiling, we found that transcript levels for Gal3st1 (also known as cerebroside sulfotransferase [CST]), known to play a ... WebFeb 2, 2024 · The orientation of CTCF motifs determines the ability of CTCF to retain cohesin and form loops 1. A comparison across our mutants showed that motifs clustered in divergent orientations block ... WebJun 22, 2024 · Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. … sialkot international airport ltd