WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in … WebJan 4, 2024 · Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM. Properties Articles 39 Spectrum Names Cryptotanshinone Biological Activity Chemical & Physical Properties MSDS Cryptotanshinone MSDS (Chinese) Safety …
Cryptotanshinone inhibits human glioma cell proliferation
WebOct 5, 2024 · Cryptotanshinone inhibited STAT3 activation in myotubes and cachectic muscles. (A) Western blot analysis of myotubes treated with TCM for 0-240 min with the indicated antibodies. (B) Myotubes were pretreated with CTS for 2 h and then stimulated with TCM for 15 min. The level of p-STAT3 (Tyr705) was determined by western blotting … WebAug 29, 2024 · DR5 and STAT3 faults reduce the value to almost half. The STAT3 inhibitor SH5-07 is unable to counter these faults. Cryptotanshinone though not able to regain the fault-free value of apoptosis, is effective in increasing apoptosis despite the … earth streamlines
A Mini-Review of the Anticancer Properties of Cryptotanshinone: A ...
WebJul 20, 2024 · Unexpectedly, imatinib activates rather than inhibits the phosphorylation of STAT3 in K562 cells. We demonstrated that cryptotanshinone, as a dual inhibitor of p-STAT5 and p-STAT3, can effectively block IL-6-mediated STAT3 activation and reverse BCR-ABL kinase-independent drug resistance. WebJul 25, 2024 · Cryptotanshinone, a natural compound extracted from the root of Salvia miltiorrhiza Bunge, has been identified as a potential STAT3 inhibitor. However, its … WebCryptotanshinone Inhibits STAT3, but Not STAT5, Signaling in K562 Cells Parallel assays were carried out in cryptotanshinone-treated K562 cells. Different from tanshinone IIA, cryptotanshinone reduced the phosphorylation level of STAT3, but not STAT5, in a dose- and time-dependent manner (Figure 3 (a) ). c - traffic light